Recombinant Mouse Urocortin-3 (Ucn3), N-His

Mouse Urocortin-3 (Ucn3) is a neuropeptide involved in the regulation of stress responses and autonomic functions. It is expressed primarily in the paraventricular nucleus of the hypothalamus and acts through the corticotropin-releasing factor receptor 2 (CRF2). Ucn3 modulates the hypothalamic-pituitary-adrenal (HPA) axis, influencing stress hormone secretion. It also plays a role in regulating feeding behavior, energy balance, and cardiovascular function. In mouse models, Ucn3 has been shown to have anxiolytic and antidepressant effects, suggesting its potential as a therapeutic target for stress-related disorders. Additionally, Ucn3 is involved in the regulation of glucose homeostasis and insulin secretion, highlighting its importance in metabolic processes.