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Recombinant Mouse Tyrosine-Protein Kinase Receptor Tie-1 (Tie1), N-His
Product Overview
BioVenic's Recombinant Mouse Tyrosine-Protein Kinase Receptor Tie-1 (Tie1), N-His is a recombinant protein expressed from E.coli. Its predicted molecular weight is 35.7 kDa. The purity is>95%.
Specifications
Target Information
Mouse Tyrosine-Protein Kinase Receptor Tie-1 (TIE1) is a receptor tyrosine kinase primarily expressed in endothelial cells. It plays a crucial role in vascular development, angiogenesis, and vessel maturation. TIE1 is considered an orphan receptor as it does not directly bind to any known ligands. However, it interacts with Tie2 and modulates Tie2 signaling. TIE1 can both positively and negatively regulate Tie2 signaling depending on the cellular context, influencing processes like vessel sprouting and stabilization. TIE1 is essential for maintaining vascular integrity and has been implicated in various vascular disorders and inflammation.
Shipping and Storage
This product is shipped with ice packs. Lyophilized protein can be stored at -80°C for 1 year. After reconstitution, the protein solution can be stored at 2-8°C for 2-7 days.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 10 mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimize freeze-thaw cycles.