Recombinant Mouse Carnitine O-Acetyltransferase (Crat), N-His

Mouse Carnitine O-Acetyltransferase (Crat) is a mitochondrial enzyme that plays a vital role in maintaining metabolic homeostasis. It catalyzes the reversible transfer of acetyl groups between acetyl-CoA and carnitine, preventing acetyl-CoA accumulation and supporting metabolic flexibility. CRAT is also crucial for fatty acid metabolism by modulating mitochondrial carbon flux and ensuring efficient fatty acid β-oxidation. Additionally, CRAT influences amino acid catabolism and mitochondrial bioenergetics. Dysregulation of CRAT activity is linked to metabolic disorders such as obesity, insulin resistance, and mitochondrial diseases. In the heart, CRAT depletion promotes cholesterol catabolism via the bile acid synthesis pathway, leading to mitochondrial stress and chronic myocardial inflammation.