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Recombinant Canine Tumor Necrosis Factor Receptor Superfamily Member 4 (TNFRSF4), C-His
Product Overview
BioVenic's Recombinant Canine Tumor Necrosis Factor Receptor Superfamily Member 4 (TNFRSF4), C-His is a recombinant protein expressed from E.coli Expression System. Its predicted molecular weight is 21.8 kDa. The purity is>90% (SDS-PAGE).
Specifications
Target Information
TNFRSF4 is a potent costimulatory receptor primarily expressed on activated T cells. In canines, it plays a critical role in enhancing T-cell proliferation, survival, and cytokine production by activating the NF-κB pathway. Within the tumor microenvironment, TNFRSF4 signaling suppresses regulatory T cell (Treg) activity while boosting effector T-cell memory. It is a key immuno-oncology target being explored for canine biologics to reverse immune suppression and stimulate robust anti-tumor responses in various solid tumors.
Shipping and Storage
This product is shipped with gel ice bags. Avoid repeated freezing and thawing. Store for 12 months at -20°C or -80°C.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Aliquote the reconstituted solution to minimise freeze-thaw cycles.