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Recombinant Chicken Interleukin-12 Subunit Beta (IL-12B), N-His
Product Overview
BioVenic's Recombinant Chicken Interleukin-12 Subunit Beta (IL-12B), N-His is a recombinant protein expressed from E.coli. Its predicted molecular weight is 37.7 kDa. The purity is>90% (SDS-PAGE).
Specifications
Target Information
Chicken Interleukin-12 Subunit Beta (IL-12B) is a critical subunit of Interleukin-12 (IL-12), primarily produced by macrophages, dendritic cells, and Langerhans cells. IL-12B combines with the IL-12A subunit to form the active IL-12 heterodimer, which activates T cells and natural killer cells, promoting interferon-γ (IFN-γ) production and enhancing cellular immune responses . In chickens, IL-12B not only participates in immune regulation but also serves as a vaccine adjuvant to enhance the host's immune response to pathogens. Additionally, IL-12B is expressed in the gut mucosa of chickens, and its expression levels change in response to Eimeria tenella infection, contrasting with IL-10, indicating its role in regulating the Th1/Th2 balance.
Shipping and Storage
This product is shipped with dry ice. It is recommended to aliquote as needed and store at -80°C upon receipt. Reconstituted protein solution can be stored at 4°C for 1 week, at < -80°C for 12 months. Avoid repeated freezing and thawing.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL.Aliquote the reconstituted solution to minimise freeze-thaw cycles.