Recombinant Mouse Protein Kinase C Delta Type (Prkcd), N-His

Mouse Protein Kinase C Delta Type (Prkcd) is a member of the protein kinase C (PKC) family, which are serine/threonine kinases involved in various cellular processes. Prkcd is activated by diacylglycerol and is known for its roles in cell proliferation, apoptosis, and differentiation. In mouse models, Prkcd has been implicated in multiple biological processes and disease states. It plays a role in the pathogenesis of chronic obstructive pulmonary disease (COPD) by promoting inflammatory response, apoptosis, mitochondrial dysfunction, and MUC5AC hypersecretion. Prkcd also contributes to B-cell signaling and autoimmunity, with its loss-of-function linked to autoimmune lymphoproliferative syndrome. Additionally, Prkcd has been studied in cancer, where it can act as both a tumor suppressor and a promoter depending on the cellular context. Its role in mediating the effects of certain drugs, such as Pasireotide in pituitary tumors, highlights its potential as a therapeutic target. Prkcd is expressed in various tissues, including the alimentary system, central nervous system, and heart, and its dysregulation has been associated with conditions like hypertension and fatty liver disease.