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Rabbit Anti-Rat Intersectin 1 (ITSN1) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for rat intersectin 1. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of rat intersectin 1.
Specifications
Target Information
Rat intersectin 1 (ITSN1) is a multi-domain adaptor protein with conserved modular structures, a core mediator of endocytic trafficking and intracellular signal transduction. It features two N-terminal Eps15 homology domains for clathrin-coated vesicle assembly, five Src homology 3 domains for protein-protein interaction, and a C-terminal Dbl homology domain critical for guanine nucleotide exchange activity. It localizes predominantly to the cytoplasm and plasma membrane of rat neuronal cells, epithelial cells and immune cells, with negligible expression in mature erythrocytes. The protein mediates the coordination of endocytosis and signaling cascades, with conserved structural motifs differentiating it from ITSN2 isoform.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.