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Rabbit Anti-Rat 15-Lipoxygenase-2 (15-LO-2) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for rat 15-lipoxygenase-2. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of rat 15-lipoxygenase-2.
Specifications
Target Information
Rat 15-lipoxygenase-2 (ALOX15B) is a 75 kDa non-heme iron enzyme whose N-terminal β-barrel and C-terminal catalytic domain insert dioxygen into arachidonic acid at carbon 15, generating 15-HPETE. A solvent-exposed 16-aa "KVE" loop (aa 420-435) between the iron-binding helix and the catalytic lid folds into a β-hairpin unique among rat lipoxygenases, presenting a conformational epitope preserved after membrane association and fixation. Affinity-purified antibodies targeting this loop trace native ALOX15B in prostatic epithelium, skin sebaceous glands, and corneal epithelium, delivering crisp cytoplasmic puncta and single-band clarity on immunoblots with no cross-reaction to 5-LOX or 12-LOX.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.