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Rabbit Anti-Rat Guanidinoacetate-N-Methyltransferase (GAMT) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for rat guanidinoacetate-N-methyltransferase. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of rat guanidinoacetate-N-methyltransferase.
Specifications
Target Information
Rat guanidinoacetate-N-methyltransferase (GAMT) is a cytosolic methyltransferase with a conserved S-adenosyl-L-methionine (SAM)-binding domain, a core mediator of endogenous creatine biosynthesis. It features an N-terminal catalytic region critical for methyl group transfer, a central substrate-binding motif for guanidinoacetate recognition, and a C-terminal domain for structural stability. It localizes predominantly to the cytoplasm of rat hepatocytes and renal tubular epithelial cells, with negligible expression in muscle or neuronal tissues. The protein mediates the rate-limiting methylation step in creatine production, with conserved structural elements differentiating it from other SAM-dependent methyltransferases.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.