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Mouse Transcription Factor GATA-4 (GATA4) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Transcription Factor GATA-4 (GATA4) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse GATA4 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Transcription factor GATA-4 is a transcriptional activator that binds to the consensus sequence 5'-AGATAG-3', playing a crucial role in cardiac development. As a key transcription factor, GATA4 ensures proper heart formation during embryonic development by regulating the migration and differentiation of cardiac progenitor cells. For instance, GATA4 expression in the second heart field (SHF) is essential for forming cardiac compartments. A deficiency in GATA4 results in cardiac developmental defects such as ventricular septal defects and ventricular hypoplasia. In adult mice, GATA4 remains important, particularly under conditions of pressure overload, where it helps protect the heart from failure by regulating cell cycle and anti-apoptotic genes.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Liu, Jielin et al. "Gata4 regulates hedgehog signaling and Gata6 expression for outflow tract development." PLoS genetics vol. 15,5 e1007711. 23 May. 2019.