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Mouse Sphingosine 1 Phosphate Lyase 1 (SGPL1) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Sphingosine 1 Phosphate Lyase 1 (SGPL1) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse SGPL1 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Sphingosine-1-phosphate lyase 1 breaks down phosphorylated sphingoid bases (PSBs), like sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine, enhancing stress-induced ceramide production and apoptosis. In mice, Sgpl1 deficiency results in significantly elevated levels of S1P and other sphingomyelins, including sphingosine, ceramide, and dihydrosphingosine. This deficiency in the liver also leads to increased cholesterol and triglyceride levels, although the liver partially compensates by secreting Sgpl1 into the blood and bile. Beyond metabolic effects, Sgpl1 is crucial for immune function; mice lacking Sgpl1 exhibit severe lymphopenia, neutrophilia, and elevated levels of pro-inflammatory cytokines such as IL-6 and TNF-α.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.