Mouse Free Fatty Acid Receptor 2 (FFAR2) ELISA Kit-Sandwich

Free fatty acid receptor 2 (FFAR2) is a G protein-coupled receptor activated by short-chain fatty acids (SCFAs), key products of dietary fiber digestion. This receptor plays a crucial role in regulating whole-body energy homeostasis and intestinal immunity. In omnivorous mammals, the gut microbiome predominantly produces SCFAs like acetate, propionate, and butyrate by metabolizing dietary fibers. These SCFAs serve not only as energy sources but also as signaling molecules. FFAR2 is likely linked to the pertussis toxin-sensitive G(i/o)-alpha family of G proteins, as well as the Gq family. Mice lacking FFAR2 demonstrate reduced pancreatic β-cell mass and impaired insulin secretion when on a high-fat diet, resulting in fasting hyperglycemia and glucose intolerance.