Mouse Complement Component 4 (C4) ELISA Kit-Sandwich

Complement component 4 serves various functions in mice, including immune defense, pathogen clearance, involvement in inflammatory responses, and potential links to neurodegenerative diseases and aging. Its role in neurodegenerative diseases has been a subject of research, particularly in the context of Alzheimer's disease (AD) models. Studies indicate that the complement system, including C4, may contribute to early synapse loss in AD. It has been observed that C1q, which initiates the classical complement activation pathway, associates with synapses and promotes their loss by enhancing microglial phagocytosis. While C3 is the primary complement factor in this process, C4 may also play a supportive role. In studies on aging in mice, the expression level of complement component 4 has been found to vary with age.