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Mouse Actin Alpha 2, Smooth Muscle (ACTa2) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Actin Alpha 2, Smooth Muscle (ACTa2) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse ACTa2 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Actins are highly conserved proteins essential for various cell motility processes and are universally expressed in all eukaryotic cells. Mutations in the Acta2 gene are a primary cause of familial thoracic aortic aneurysms and dissections. These mutations result in VSMC dysfunction, characterized by excessive proliferation of vascular smooth muscle and irregular elastic fibers. For instance, Acta2-deficient mice exhibit dilation of the aortic root due to disordered elastic fibers and reduced extracellular matrix remodeling capacity. Additionally, Acta2 mutations increase blood vessels' sensitivity to angiotensin II (AngII), thereby exacerbating vasodilation and inflammatory responses.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.