Recombinant Rabbit Protein-Glutamine Gamma-Glutamyltransferase K (TGM1)

Rabbit Protein-Glutamine Gamma-Glutamyltransferase K (TGM1), also known as Transglutaminase 1, is a key enzyme involved in post-translational modifications of proteins, particularly in crosslinking reactions. It catalyzes the formation of covalent bonds between glutamine and lysine residues, leading to the stabilization of protein networks. In rabbits, TGM1 plays a crucial role in various physiological processes, including the formation of the cornified envelope in the skin, which is essential for maintaining the skin barrier. Additionally, TGM1 is involved in maintaining endothelial barrier function in the vasculature, contributing to vascular stability and remodeling. Its activity is also implicated in the pathophysiology of several diseases, such as fibrosis and neurodegenerative conditions, where it contributes to tissue remodeling and protein aggregation. In summary, TGM1 is a multifunctional enzyme with broad implications in tissue integrity, immune responses, and disease progression.