Recombinant Mouse Platelet-Activating Factor Acetylhydrolase (Pla2g7), N-His

In mice, Platelet-Activating Factor Acetylhydrolase (Pla2g7) is a phospholipase involved in the hydrolysis of platelet-activating factor and truncated phospholipids. It is a component of lipoprotein-associated phospholipase A2 (LP-PLA2) and is upregulated in activated macrophages and atherosclerotic plaque foam cells. Pla2g7 plays roles in inflammation, atherosclerosis, and immune responses. It has been implicated in various diseases, including cardiovascular diseases, diabetes, and cancer. In cancer, Pla2g7 can promote immune evasion by regulating the JAK-STAT pathway and PD-L1 expression. Additionally, studies show that Pla2g7 depletion or inhibition can enhance the efficacy of immunotherapies and reduce inflammation. In metabolic contexts, Pla2g7 is involved in adipose tissue metabolism and energy balance, with its downregulation associated with improved metabolic health and longevity.