Recombinant Mouse Alpha-1-Acid Glycoprotein 1 (Orm1)

In mice, Alpha-1-Acid Glycoprotein 1 (Orm1) is an acute-phase protein primarily synthesized in the liver. It plays a role in the inflammatory response and is upregulated during stress, infection, or injury. Orm1 is involved in various physiological processes, including immune modulation and metabolic regulation. Studies show that Orm1 can bind to leptin receptors in the hypothalamus, inhibiting food intake and influencing glucose metabolism. In cancer research, Orm1 has been linked to tumor progression, particularly in colorectal cancer liver metastasis, where it promotes macrophage M2 polarization, creating a pro-tumor immune microenvironment. Orm1 is also associated with liver regeneration and fibrosis, with its expression increasing during liver injury and regeneration. Overall, Orm1 is a multifunctional protein with applications in studying inflammation, cancer, and metabolic disorders.