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Rabbit Anti-Rat Lymphocyte Activation Gene 3 (LAG3) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for rat lymphocyte activation gene 3. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of rat lymphocyte activation gene 3.
Specifications
Target Information
Rat lymphocyte activation gene 3 (LAG3) is a transmembrane glycoprotein of the immunoglobulin superfamily, a critical immune checkpoint receptor. It features four conserved extracellular Ig-like domains, a single transmembrane segment, and a cytoplasmic tail with multiple phosphorylation motifs critical for structural stability and signal transduction. It localizes to the cell membranes of rat activated T lymphocytes, natural killer cells and dendritic cells, with negligible levels in resting immune cells and non-immune tissues. The protein mediates T-cell activation inhibition and immune tolerance modulation, with conserved motifs for ligand binding and downstream signaling. Rat LAG3 shares core functional domains with mammalian orthologs, and has distinct binding affinity differentiating it from CD4 and other Ig-superfamily receptors.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.