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Rabbit Anti-Rat Haptoglobin (Hpt) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for rat haptoglobin. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of rat haptoglobin.
Specifications
Target Information
Rat haptoglobin (Hp) is a secreted glycoprotein of the globin-binding protein family, a key regulator of hemoglobin clearance and iron homeostasis. It features conserved N-terminal α-subunits and C-terminal β-subunits linked by disulfide bonds, a hemoglobin-binding domain, and structural motifs critical for ligand interaction and stability. It localizes to rat plasma and extracellular fluids, with high expression in hepatocytes and negligible levels in non-hepatic tissues. The protein mediates hemoglobin-haptoglobin complex formation and macrophage uptake, with conserved binding sites for hemoglobin and CD163 receptors. Rat Hp shares core functional domains with mammalian orthologs, and has distinct binding affinity differentiating it from other plasma glycoproteins.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.