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Rabbit Anti-Rat Cytokeratin 14 (CK14) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for rat cytokeratin 14. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of rat cytokeratin 14.
Specifications
Target Information
Rat cytokeratin 14 (CK14, KRT14) is a 50 kDa type I intermediate filament protein comprising 472 residues. It pairs with keratin 5 to form stable heterodimers that assemble into 10 nm tonofilaments, anchored at hemidesmosomes via its N-terminal head domain and L12 linker. Expressed constitutively in basal keratinocytes of stratified epithelia, mammary myoepithelium and stratified squamous mucosa, CK14 localizes to cytoplasmic filament bundles and perinuclear cages. The protein undergoes phosphorylation during mitosis and binds plectin at residues 1-75. Antibodies raised against rod domain or C-terminal peptide detect native, phosphorylated and soluble forms with negligible cross-reactivity to other keratins, enabling precise immunoblot and immunohistochemical detection in rat skin, esophagus and cultured primary keratinocytes.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.