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Rabbit Anti-Rat Programmed Cell Death Protein 1 (PD1) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for rat programmed cell death protein 1. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of rat programmed cell death protein 1.
Specifications
Target Information
Rat programmed cell death protein 1 (PD-1) is a 288-residue type I transmembrane glycoprotein belonging to the CD28 superfamily, featuring a single extracellular IgV-like domain, a 20-amino-acid stalk, and a cytoplasmic tail harboring two tyrosine-based signaling motifs. Expressed on activated T and B lymphocytes, myeloid cells, and select thymocyte subsets, the receptor undergoes phosphorylation upon ligand engagement, recruiting SHP-1 and SHP-2 phosphatases. Its expression is transiently up-regulated during immune activation and can be retained on exhausted lymphocytes. Antibodies targeting rat PD-1 specifically recognize the native extracellular epitope with minimal cross-reactivity to CD28, CTLA-4, or other IgV receptors, enabling precise detection in lymphoid tissues and cultured immune cells.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.