Mouse Small Ubiquitin Related Modifier Protein 1 (SUMO1) ELISA Kit-Sandwich

Small ubiquitin-related modifier 1 (SUMO1) is a protein similar to ubiquitin that can be attached to other proteins either as a single unit (monomer) or as a chain linked through lysine residues. This covalent attachment occurs via an isopeptide bond and requires activation by the E1 complex, composed of SAE1-SAE2, as well as linkage to the E2 enzyme UBE2I. E3 ligases, like PIAS1-4, RANBP2, or CBX4, can facilitate this process. SUMO1 plays a crucial role in the nervous system. Research indicates that overexpressing SUMO1 may impair synaptic function, decrease dendritic spine density, and undermine learning and memory, particularly affecting synaptic transmission and memory formation in the hippocampus. Additionally, SUMO1's SUMOylation in neurons impacts the localization and functionality of various proteins, including synapse-related proteins like synaptotagmin-1.