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Mouse Glucosidase Alpha, Acid (GaA) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Glucosidase Alpha, Acid (GaA) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse GaA in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Lysosomal alpha-glucosidase is crucial for glycogen degradation within lysosomes. It exhibits the highest activity on alpha-1,4-linked glycosidic linkages but can also hydrolyze alpha-1,6-linked glucans. In mice, the function of lysosomal acid alpha-glucosidase (GAA) is closely associated with hereditary glycogen storage disease type II (GSDII or Pompe disease). GAA is the lysosomal enzyme responsible for breaking down α-1,4 and α-1,6 bonds in glycogen. A deficiency in GAA results in the accumulation of glycogen within lysosomes, leading to cell and tissue damage. Mice with a knockout of the GAA gene exhibit significant glycogen accumulation in the heart and skeletal muscles, accompanied by abnormal dilation and vacuolization of lysosomes.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.