Mouse DOT1 Like, Histone H3 Methyltransferase (DOT1L) ELISA Kit-Sandwich

DOT1L is crucial for embryonic development and hematopoiesis. Research indicates that the absence of DOT1L can result in delayed embryonic development and embryonic death at the mesoderm stage, characterized by severe anemia and defects in erythrocyte development. Additionally, DOT1L functions as a transcriptional repressor in hematopoietic stem cells and early hematopoietic progenitor cells, influencing their proliferation and differentiation through gene expression regulation. In brain development, DOT1L impacts the formation and function of neuronal layers by controlling neuron proliferation and differentiation. Studies have shown that the lack of DOT1L can cause abnormal cortical development in the vestibular cerebellum of mice, resulting in reduced granule cell numbers and impaired neuronal differentiation.