Mouse ATPase, Na+/K+ Transporting Beta 1 Polypeptide (ATP1b1) ELISA Kit-Sandwich

Atp1b1 serves as the non-catalytic component of the active enzyme that facilitates ATP hydrolysis, coupled with the exchange of Na+ and K+ ions across the plasma membrane. The beta subunit regulates the number of sodium pumps transported to the plasma membrane by assembling alpha/beta heterodimers. ATP1B1 is critical in the kidney, particularly in the reabsorption of sodium and potassium by the renal tubules. Research has demonstrated that ATP1B1 gene expression is modulated by several signaling pathways, including calcium ion (Ca²⁺) and cyclic adenosine monophosphate (cAMP) pathways, which affect ATP1B1 transcription via phosphorylation or dephosphorylation of the SIMK1 protein. In a non-alcoholic steatohepatitis (NASH) model, ATP1B1 expression is significantly upregulated, and its inhibition can decrease the release of inflammatory factors, thus protecting the liver from further damage. In mice on a high-fat diet, ATP1B1 expression levels were notably reduced, but they were restored on the DAPA diet.