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Mouse Arachidonate-5-Lipoxygenase (ALOX5) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Arachidonate-5-Lipoxygenase (ALOX5) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse ALOX5 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Polyunsaturated fatty acid 5-lipoxygenase catalyzes the oxygenation of arachidonate to 5-hydroperoxyeicosatetraenoate (5-HPETE), followed by its dehydration to 5,6-epoxyeicosatetraenoate (Leukotriene A4/LTA4). These steps are the initial stages in the biosynthesis of leukotrienes, which are powerful inflammation mediators. In mice, the Alox5 gene is pivotal in the pathogenesis of chronic myeloid leukemia (CML). Research indicates that loss or inhibition of Alox5 significantly impacts the function of leukemia stem cells (LSCs), leading to their inability to form tumors in the BCR-ABL-induced mouse CML model. Specifically, Alox5-deficient mouse LSCs lose their normal self-renewal capability and cannot effectively invade the bone marrow of recipient mice.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.