Recombinant Rabbit Lipopolysaccharide-Binding Protein (LBP), N-His

Rabbit Lipopolysaccharide-Binding Protein (LBP) is a key acute-phase protein that plays a crucial role in the immune response to bacterial infections, particularly those caused by Gram-negative bacteria. LBP binds to lipopolysaccharide (LPS), a component of the bacterial cell wall, and enhances the immune response by facilitating the interaction between LPS and immune cells. In rabbits, LBP is synthesized by hepatocytes and its expression increases during inflammation. It helps in the recognition and neutralization of LPS, thereby reducing the harmful effects of bacterial endotoxins. LBP also promotes the activation of immune cells such as macrophages and enhances the production of pro-inflammatory cytokines like TNF-α. This protein is essential for the early detection and response to bacterial infections, making it a vital component of the host defense mechanism.