Recombinant Mouse RNA-Binding Protein FUS (Fus), N-His

Mouse RNA-Binding Protein FUS (Fus) is a multifunctional protein involved in various aspects of RNA metabolism, including transcription, alternative splicing, and mRNA transport. It plays a crucial role in neurons, where it regulates the expression of genes coding for RNA-binding proteins by binding to their conserved introns. FUS is also implicated in neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD), where its mislocalization or aggregation can lead to neuronal degeneration. In mouse models, FUS is essential for maintaining synaptic function and dendritic spine morphology, with its depletion leading to significant abnormalities. Additionally, FUS is involved in stress granule formation and stability, which are important for cellular responses to stress.