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Recombinant Mouse Alkaline Phosphatase, Tissue-Nonspecific Isozyme (Alpl), N-His
Product Overview
BioVenic's Recombinant Mouse Alkaline Phosphatase, Tissue-Nonspecific Isozyme (Alpl), N-His is a recombinant protein expressed from E.coli. Its predicted molecular weight is 37.2 kDa. The purity is> 97%.
Specifications
Target Information
Mouse Alkaline Phosphatase, Tissue-Nonspecific Isozyme (Alpl) is a crucial enzyme involved in bone metabolism and development. It is expressed in osteoblasts and plays a significant role in bone mineralization by hydrolyzing inorganic pyrophosphate (PPi) and pyridoxal 5'-phosphate (PLP). Alpl deficiency is associated with hypophosphatasia, a severe skeletal disorder characterized by reduced bone mineralization and increased risk of fractures. In addition to its role in bone health, Alpl has been implicated in immune regulation and cancer progression. Recent studies have shown that Alpl can influence the fate of mesenchymal stem cells (MSCs) by regulating ATP release and the AMPKα signaling pathway, thereby affecting bone aging.
Shipping and Storage
This product is shipped with ice packs. Lyophilized protein can be stored at -80°C for 1 year. After reconstitution, the protein solution can be stored at 2-8°C for 2-7 days.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 10 mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimize freeze-thaw cycles.