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Rabbit Anti-Mouse Alpha-Hemoglobin Stabilizing Protein (aHSP) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse alpha-hemoglobin stabilizing protein. It is purified by protein A/G. It can be applied to WB and IHC assays of mouse alpha-hemoglobin stabilizing protein.
Specifications
Target Information
Mouse alpha-hemoglobin-stabilizing protein (AHSP) is a 102-residue, 12 kDa cytosolic chaperone expressed exclusively in erythroid precursors. Its central β-barrel (residues 20-90) presents a hydrophobic groove that clamps free α-globin, preventing precipitation until assembly with β-globin. A conserved Tyr at position 52 coordinates heme iron, stabilizing the bound cofactor. The protein localizes to cytosol and ribosomal periphery during reticulocyte maturation. Antibodies raised against full-length recombinant mouse AHSP detect native, heme-bound and oxidized forms with negligible cross-reactivity to β-globin or other erythroid chaperones, enabling precise immunoblot and immunohistochemical detection in mouse hematopoietic tissues and cultured erythroid precursors.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.