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Rabbit Anti-Mouse Agrin (AGRN) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse agrin. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of mouse agrin.
Specifications
Target Information
Mouse Agrin is a secreted heparan sulfate proteoglycan, a key regulator of postsynaptic differentiation and neuromuscular junction (NMJ) formation. It features conserved N-terminal laminin G-like domains, central follistatin-like modules, and C-terminal LG domains critical for receptor binding and signaling activation. It localizes to the extracellular matrices of mouse skeletal muscles, central nervous system tissues and NMJs, with negligible levels in hematopoietic and epithelial tissues. The protein mediates acetylcholine receptor clustering via MuSK-LRP4 complex interaction, with conserved motifs for heparan sulfate modification and cell adhesion. Mouse Agrin shares core functional domains with mammalian orthologs, and has distinct tissue specificity differentiating it from other synaptic proteoglycans.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.