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Rabbit Anti-Cortisone (Cor) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for cortisone. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of cortisone.
Specifications
Target Information
Cortisone is a 21-carbon glucocorticoid characterized by an 11-keto group that distinguishes it from its reversible reduction product cortisol. Synthesized in the adrenal zona fasciculata through 11β-hydroxysteroid dehydrogenase type 2 oxidation of cortisol, the steroid circulates bound to corticosteroid-binding globulin and albumin. Its planar Δ4-3-one A-ring and polar dihydroxyacetone side chain confer low intrinsic glucocorticoid activity, yet serve as a metabolic reservoir for rapid cortisol regeneration in target tissues. Antibodies generated against cortisone-carrier conjugates exhibit high specificity over cortisol, corticosterone and related pregnanes, enabling direct measurement of the 11-oxo steroid in serum, urine and tissue matrices.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.