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Mouse Anti-Mouse Beta-2-Microglobulin (b2M) Monoclonal Antibody
Product Overview
BioVenic mouse monoclonal antibody is specific for mouse beta-2-microglobulin. It is affinity purified by protein A and protein G . It can be applied to WB, IHC, ICC and IP assays of mouse beta-2-microglobulin.
Specifications
Target Information
Mouse Beta-2-Microglobulin (B2M) is a 12-14 kDa protein that forms a subunit of the major histocompatibility complex (MHC) class I molecules. It is expressed on the surface of all nucleated cells, including lymphocytes, monocytes, and epithelial cells, but is absent on erythrocytes. B2M is essential for the stability and cell surface expression of MHC class I heavy chains, playing a crucial role in antigen presentation to cytotoxic T cells. Additionally, it is involved in TCR signaling and downstream signaling in naive CD8+ cells.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 2 years). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Staats, Kim A., et al. "Beta-2 microglobulin is important for disease progression in a murine model for amyotrophic lateral sclerosis." Frontiers in Cellular Neuroscience 7 (2013): 249.