Recombinant Mouse Oxidized Low-Density Lipoprotein Receptor 1 (Olr1), N-His

Mouse Oxidized Low-Density Lipoprotein Receptor 1 (Olr1), also known as LOX-1, is a C-type lectin receptor that plays a crucial role in lipid metabolism and inflammation. It is highly expressed in tissues with abundant vasculature, such as the placenta, lung, and brain. Olr1 binds and internalizes oxidized low-density lipoprotein (oxLDL), contributing to endothelial dysfunction and atherosclerosis. In mouse models, Olr1 deficiency has been shown to reduce atherosclerotic plaque formation and improve outcomes in ischemic stroke. Additionally, Olr1 is involved in the inflammatory response and can mediate the uptake of oxLDL by macrophages, leading to foam cell formation and plaque instability. In the context of intracerebral hemorrhage, Olr1 knockdown has been shown to reduce brain damage, inflammation, and oxidative stress, suggesting its potential as a therapeutic target.