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Recombinant Bovine Probetacellulin (BTC), N-His
Product Overview
BioVenic's Recombinant Bovine Probetacellulin (BTC), N-His is a recombinant protein expressed from E.coli. Its predicted molecular weight is N/A. The purity is>97% (SDS-PAGE).
Specifications
Target Information
Bovine betacellulin (bTC) is a member of the epidermal growth factor (EGF) family, which is known to play a significant role in the growth and differentiation of various cell types, including pancreatic beta cells
. In cattle, bTC is expressed in a wide range of tissues and is particularly abundant in the mammary gland, suggesting its importance in milk for the growth and development of the neonatal gastrointestinal tract
. It is also involved in immune regulation and has been identified as a major peptide growth factor in milk, with potential roles in the maintenance of skin homeostasis and the promotion of cell proliferation and differentiation
. bTC's effects are mediated through binding to EGFR and other ErbB receptors, activating signaling pathways critical for cell proliferation, migration, and differentiation.
Shipping and Storage
This product is shipped with dry ice. It is recommended to aliquot as needed and store at -80°C upon receipt. Reconstituted protein solution can be stored at 4°C for 1 week, at < -80°C for 12 months. Avoid repeated freezing and thawing.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimise freeze-thaw cycles.
References
- Dunbar, A J. et al.Identification of betacellulin as a major peptide growth factor in milk: purification, characterization and molecular cloning of Sheep betacellulin. The Biochemical journal 1999, 344 Pt 3,Pt 3: 713-21.