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Rabbit Anti-Rat Integrin Alpha D (ITGaD) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for rat integrin alpha D. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of rat integrin alpha D.
Specifications
Target Information
Rat integrin αD (ITGAD) is a 1,145-residue type I transmembrane glycoprotein that pairs exclusively with β2 to form the αDβ2 heterodimer. Its extracellular region contains a seven-bladed β-propeller, an α-β hybrid domain, three calcium-binding thighs, four EGF-like repeats and a novel C-terminal calf domain that stabilizes the bent conformation. The cytoplasmic tail carries an internal GFFKR motif and two threonine-rich inserts that regulate Rap1 binding. Restricted to myeloid lineage, αD is abundant on splenic macrophages, dendritic cells and activated granulocytes. Antibodies raised against the rat-specific calf-2 peptide detect native αDβ2 heterodimers with negligible cross-reactivity to αM, αX or other integrin α chains, enabling selective immunoblot and flow-cytometric detection in rat leukocytes and tissue homogenates.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.