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Rabbit Anti-Rat Caspase 8 (CASP8) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for rat caspase 8. It is affinity purified by protein A. It can be applied to WB, IHC, ICC and IP assays of rat caspase 8.
Specifications
Target Information
Rat caspase 8 is a key initiator caspase in the extrinsic apoptotic pathway. It is activated by the binding of death receptors, such as Fas and TNF receptors, leading to the formation of the death-inducing signaling complex (DISC). Once activated, caspase 8 cleaves downstream effector caspases, triggering apoptosis. It is expressed in various tissues and plays a crucial role in maintaining cellular homeostasis by regulating programmed cell death. Caspase 8 is essential for normal development and immune function, and its dysfunction is implicated in diseases associated with abnormal cell survival or death. As a central regulator of apoptosis, caspase 8 is an important target for studying cell death mechanisms and related disorders.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 2 years). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.