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Rabbit Anti-Mouse Tyrosine Kinase 2 (Tyk2) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse tyrosine kinase 2. It is purified by protein A/G. It can be applied to WB assays of mouse tyrosine kinase 2.
Specifications
Target Information
Mouse tyrosine kinase 2 (TYK2) is a cytoplasmic non-receptor tyrosine kinase of the Janus kinase (JAK) family, a core mediator of cytokine signaling. It features a conserved N-terminal FERM domain, a pseudokinase region, a C-terminal catalytic kinase domain, and cytokine receptor-binding motifs critical for structural integrity and signal transduction. It localizes to the cytoplasm of mouse immune cells, including lymphocytes and myeloid cells, with negligible levels in non-hematopoietic tissues. The protein mediates tyrosine phosphorylation and JAK-STAT pathway activation, with conserved motifs for ATP binding and substrate phosphorylation. Mouse TYK2 shares core functional domains with mammalian orthologs, and has distinct cytokine selectivity differentiating it from JAK1, JAK2 and JAK3.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.