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Rabbit Anti-Mouse Proliferating Cell Nuclear Antigen (PCNA) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse proliferating cell nuclear antigen. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of mouse proliferating cell nuclear antigen.
Specifications
Target Information
Mouse proliferating cell nuclear antigen (PCNA) is a 29 kDa toroidal homotrimer whose inter-domain connector loop and C-terminal tail embrace DNA, encircling the helix to tether replicative polymerases and sliding factors. A solvent-exposed 12-aa "KVE" surface loop (aa 164-175) between β-sheets 12 and 13 folds into a β-hairpin unique among mouse DNA clamp proteins, presenting a conformational epitope preserved after nucleotide incorporation and fixation. Antibodies targeting this loop trace native PCNA in S-phase nuclei, replication foci, and repair patches, delivering crisp nuclear puncta and single-band clarity on immunoblots with no cross-reaction to the 9-1-1 clamp or other sliding clamps.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.