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Rabbit Anti-Mouse Glucokinase (GCK) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse glucokinase. It is affinity purified by protein A. It can be applied to WB, IHC, ICC and IP assays of mouse glucokinase.
Specifications
Target Information
Mouse Glucokinase (GCK) is a key enzyme in glucose metabolism, catalyzing the phosphorylation of glucose to glucose-6-phosphate (G6P) in a reaction dependent on glucose concentration. Unlike other hexokinases, GCK has a low affinity for glucose and is not inhibited by its product, G6P. This unique property allows GCK to function as a glucose sensor, regulating insulin secretion in pancreatic β-cells and glycogen synthesis in the liver. GCK is also expressed in other tissues, including the intestine, hypothalamus, and adrenal gland, where it contributes to glucose homeostasis.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 2 years). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Grimsby, Joseph, et al. "Characterization of glucokinase regulatory protein-deficient mice." Journal of Biological Chemistry 275.11 (2000): 7826-7831.