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Mouse Anti-Rat Caspase 8 (CASP8) Monoclonal Antibody
Product Overview
BioVenic mouse monoclonal antibody is specific for rat caspase 8. It is affinity purified by protein A and protein G . It can be applied to WB, IHC, ICC and IP assays of rat caspase 8.
Specifications
Target Information
Rat caspase 8 is a key initiator caspase in the extrinsic apoptotic pathway. It is activated by the binding of death receptors, such as Fas and TNF receptors, leading to the formation of the death-inducing signaling complex (DISC). Once activated, caspase 8 cleaves downstream effector caspases, triggering apoptosis. It is expressed in various tissues and plays a crucial role in maintaining cellular homeostasis by regulating programmed cell death. Caspase 8 is essential for normal development and immune function, and its dysfunction is implicated in diseases associated with abnormal cell survival or death. As a central regulator of apoptosis, caspase 8 is an important target for studying cell death mechanisms and related disorders.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 2 years). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.