Recombinant Mouse Prostatic Acid Phosphatase (Acp3), N-His

Mouse Prostatic Acid Phosphatase (Acp3) is an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. Acp3 is involved in various biological processes, including nucleobase-containing small molecule metabolic processes and the regulation of sensory perception of pain. It is expressed in the epithelium of the phallic urethra of both female and male mice, as well as in the genital tubercle mesenchyme of female mice and the urethral plate. Acp3 has been used to study prostate cancer, and its human orthologs are implicated in prostate cancer. Additionally, Acp3 plays a role in the regulation of salivation in male mice by acting as the main acid phosphatase with 5'-ectonucleotidase activity in male mouse saliva. It also participates in the metabolism of extracellular nucleotides, which is involved in the regulation of taste signaling in taste buds. Furthermore, Acp3 is required for the antinociceptive effects of thiamine and benfotiamine, and it interacts with snapin, with deficient mice developing prostate adenocarcinoma. Research indicates that Acp3 is a prostate-specific tumor suppressor and is involved in the control of GABAergic tone in the brain.