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Rabbit Anti-Quinolinic Acid (QA) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for quinolinic acid. It is purified by protein A/G. It can be applied to ELISA, CLIA/IHC-Fr and ICC assays of quinolinic acid.
Specifications
Target Information
Quinolinic acid is a dicarboxylic pyridine derivative bearing a carboxyl group at positions 2 and 3 of the heteroaromatic ring, giving it a net negative charge at physiological pH. Generated within the kynurenine branch of tryptophan catabolism, the molecule accumulates in activated microglia and infiltrating macrophages where it functions as an endogenous N-methyl-D-aspartate receptor agonist. Its compact planar structure allows rapid diffusion across membranes, while the twin carboxylates confer water solubility and chelating capacity for divalent cations. Antibodies produced against quinolinic acid-protein conjugates selectively recognize the free acid with negligible binding to picolinic, kynurenic or other kynurenine pathway intermediates.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.