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Rabbit Anti-Mouse Granzyme B (GZMB) Polyclonal Antibody

Name: Rabbit Anti-Mouse Granzyme B (GZMB) Polyclonal Antibody
SKU: VD2N32
Rating: 5 (1 reviews)

Cat. No.VD2N32

Product TypeAnimal-targeted Antibodies

Size

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Product Overview

BioVenic rabbit polyclonal antibody is specific for mouse granzyme B. It is affinity purified by protein A. It can be applied to WB, IHC, ICC and IP assays of mouse granzyme B.

Specifications

Application WB; IHC; ICC; IP

Clonality Polyclonal

Classification Primary Antibody

Clone A13N10

Host Rabbit

Target Species Mouse

Species Reactivity Mouse

Specificity Mouse Granzyme B

Isotype IgG

Immunogen Recombinant protein of mouse granzyme B

Purification Protein A Purified

Concentration 0.5 mg/mL

Conjugation Unconjugated

Preservative and Stabilizer 0.05% Proclin 300

Buffer 0.01M Phosphate Buffered Saline, pH 7.4, with 50% Glycerol

Physical State Liquid

Target Information

Mouse granzyme B is a serine protease primarily expressed by cytotoxic T lymphocytes and natural killer cells. It is a critical component of the immune system's cytotoxic response, delivered into target cells via granule exocytosis. Granzyme B induces apoptosis by cleaving key intracellular substrates, including members of the caspase family, leading to cell death. This protease is essential for eliminating infected or transformed cells, maintaining immune homeostasis, and protecting against pathogens.

Target Mouse Granzyme B

Target Synonym GZM-B; HLP; CTLA1; CCPI; CGL1; CSP-B; CSPB; CTSGL1; SECT; Granzyme 2; Cytotoxic T-Lymphocyte-Associated Serine Esterase 1; Fragmentin 2; Cytotoxic Serine Protease B

Gene ID 14939

UniProt ID P04187

Shipping and Storage

This product is shipped with wet ice packs. Store at -20°C on receipt (up to 2 years). Avoid repeated freezing and thawing as this may denature the antibody.

Documents

Datasheet

COA

To request a Certificate of Analysis, please enter the Lot No. in the search box. Note: Certificate of Analysis not available for kits.

The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.

References

Casciola-Rosen, Livia, et al. "Mouse and human granzyme B have distinct tetrapeptide specificities and abilities to recruit the bid pathway." Journal of Biological Chemistry 282.7 (2007): 4545-4552.