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Mouse Mucin 1 (MUC1) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Mucin 1 (MUC1) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse MUC1 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
The alpha subunit of Mucin-1 possesses cell adhesive properties and can function as both an adhesion and anti-adhesion protein. It may offer a protective layer on epithelial cells against bacterial and enzyme attacks. The beta subunit contains a C-terminal domain involved in cell signaling through phosphorylations and protein-protein interactions. MUC1 is a transmembrane glycoprotein overexpressed in various cancers and is highly expressed in over 90% of human breast cancers. Research has demonstrated that MUC1 plays a significant role in mouse breast cancer models. For instance, in C3H/HeOuJ mice, immunization with a MUC1 fusion protein containing ten repeat sequences significantly reduced the incidence of breast cancer. In the DSS-induced mouse colitis model, the expression of MUC1 and MUC2 was inhibited, highlighting their importance in maintaining the integrity of the intestinal barrier. Additionally, MUC1 is involved in regulating tight junctions and apoptosis of intestinal epithelial cells, thereby influencing the onset of inflammation.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Ganieva, Umida et al. "IL-22 regulates endometrial regeneration by enhancing tight junctions and orchestrating extracellular matrix." Frontiers in immunology vol. 13 955576. 25 Aug. 2022.