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Park7 Knockout Mouse Hippocampal Neuron Cell Line-HT22
Product Overview
Mouse Hippocampal Neuron Cell Line-HT22 is a subclone of HT-4 and is highly sensitive to glutamate, making it frequently used as a research model for glutamate-induced neurotoxicity. Through induced differentiation, HT-22 cells can exhibit characteristics closer to those of mature hippocampal neurons, thereby playing an important role in the study of neurodegenerative diseases, neuroinflammation, neuroprotection, and drug screening. The Park7 gene in this cell line was knocked out by gene editing.
Specifications
Target Information
The Park7 gene in this cell line was knocked out by gene editing. The Park7 (PARK7) gene, also known as the DJ-1 gene, is closely associated with autosomal recessive early-onset Parkinson's disease (PD). The protein encoded by this gene, DJ-1, has multiple functions within cells, including acting as a sensor for oxidative stress, a molecular chaperone, and participating in the Ras signaling pathway.
Shipping and Storage
This product is shipped with dry ice. It's recommended to store the product with liquid nitrogen and never in a -20 °C or -80 °C refrigerator. Avoid repeated freezing and thawing of the product.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.