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Rat Myocardial Fibroblasts-Immortalized by SV40T Antigens
Product Overview
Rat Myocardial Fibroblasts play a crucial role in heart diseases such as myocardial fibrosis, myocardial infarction, and diabetic cardiomyopathy. In the heart, cardiac fibroblasts account for approximately 60%-70% of the total cells in normal myocardial tissue, making them the main component of non-myocardial cells in the heart. They are widely distributed throughout the cardiac tissue, surrounding cardiomyocytes and connecting the myocardial interstitium, and are closely associated with pathological conditions like ischemic heart disease, inflammation, hypertrophy, and infarction. These cells were immortalized through lentiviral transfection carrying the SV40 gene (these cells acquire puromycin resistance after transfection).
Specifications
Target Information
These cells are transformed and stably express the large T-antigen of the simian virus 40 (SV40T antigens) to immortalize the cells and extend their lifespan.
Shipping and Storage
This product is shipped with dry ice. It's recommended to store the product with liquid nitrogen and never in a -20 °C or -80 °C refrigerator. Avoid repeated freezing and thawing of the product.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.