Recombinant Mouse Prohibitin 1 (Phb1), N-His

Mouse Prohibitin 1 (Phb1) is a highly conserved protein that plays a crucial role in regulating mitochondrial function and cellular processes. It is widely expressed in various tissues and is involved in cell proliferation, apoptosis, cell cycle regulation, and immune responses. Phb1 is localized to the inner mitochondrial membrane and interacts with other mitochondrial proteins to maintain membrane integrity and regulate mitochondrial dynamics. In mouse models, Phb1 has been implicated in multiple biological processes and disease states. It is essential for maintaining mitochondrial function and has been studied in the context of cancer, cardiovascular diseases, and immune responses. Phb1 has been shown to promote castration resistance in prostate cancer by mediating androgen receptor signaling and MAPK pathway activation. Conversely, in liver cancer, Phb1 acts as a tumor suppressor by inhibiting cell proliferation and inducing apoptosis through the p53-mediated mitochondrial pathway. Additionally, Phb1 regulates mitochondrial DNA release and downstream inflammatory responses, highlighting its role in innate immunity and sepsis.