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Rat Basophilic Leukemia Cell Line-RBL-2H3

Product Overview

Rat Basophilic Leukemia Cell Line-RBL-2H3 is a basophilic leukemia cell line isolated and cloned from basophils maintained in a tumor state in Wistar rats. These cells possess high-affinity IgE receptors. They can be activated to secrete histamine and other mediators by aggregating these receptors or by co-stimulating with calcium ionophores. This cell line is widely used to study the biochemical pathways of mast cell FcεRI and secretion. RBL-2H3 cells serve as a model for investigating FcεRI structure. They are extensively utilized to study various aspects of cellular secretion, including changes in intracellular calcium concentration, phospholipase activation, and the roles of protein kinases and small G proteins.

Specifications

Cell Product Type Cell Line

Species Rat

Cell Type Tumor Cell Line

Source Peripheral Blood

Disease Basophilic Leukemia

Growth Information Adherent; 37°C; 5%CO₂

Quality Control Mycoplasma (-); Bacteria (-); Yeast (-); Fungi (-)

Formulation and Cell Culture Medium MEM with 15% FBS; 1% Penicillin-Streptomycin Solution

Physical State Frozen cells

Shipping and Storage

This product is shipped with dry ice. It's recommended to store the product with liquid nitrogen and never in a -20 °C or -80 °C refrigerator. Avoid repeated freezing and thawing of the product.

Documents

Datasheet

COA

To request a Certificate of Analysis, please enter the Lot No. in the search box. Note: Certificate of Analysis not available for kits.

The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.