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Mouse Bone Marrow Stromal Cell Line-OP9

Product Overview

Mouse Bone Marrow Stromal Cell Line-OP9 originated from the calvaria of newborn op/op mice. Due to a mutation in the gene encoding M-CSF, it cannot produce functional macrophage colony-stimulating factor (M-CSF). The presence of M-CSF has an inhibitory effect on the differentiation of embryonic stem (ES) cells into hematopoietic cells rather than other macrophage types. OP9 cells can be co-cultured with mouse embryonic stem cells to induce the differentiation of ES cells into erythroid, myeloid, and B-lymphoid lineage blood cells. Co-culturing with OP9 does not require exogenous growth factors or complex embryonic structures. This system is useful for studying the molecular mechanisms of hematopoietic cell development and differentiation.

Specifications

Cell Product Type Cell Line

Species Mouse

Cell Type Fibroblasts

Source Bone Marrow

Growth Information Adherent; 37°C; 5%CO₂

Quality Control Mycoplasma (-); Bacteria (-); Yeast (-); Fungi (-)

Formulation and Cell Culture Medium MEMα with 20% FBS; 1% Penicillin-Streptomycin Solution

Physical State Frozen cells

Shipping and Storage

This product is shipped with dry ice. It's recommended to store the product with liquid nitrogen and never in a -20 °C or -80 °C refrigerator. Avoid repeated freezing and thawing of the product.

Documents

Datasheet

COA

To request a Certificate of Analysis, please enter the Lot No. in the search box. Note: Certificate of Analysis not available for kits.

The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.